I am a
Home I AM A Search Login

Papers of the Week

Papers: 2 Apr 2022 - 8 Apr 2022

Human Studies


Front Oncol


Solid Tumor Opioid Receptor Expression and Oncologic Outcomes: Analysis of the Cancer Genome Atlas and Genotype Tissue Expression Project.


Belltall A, Zúñiga-Trejos S, Garrido-Cano I, Eroles P, Argente-Navarro M P, Buggy DJ, Díaz-Cambronero O, Mazzinari G
Front Oncol. 2022; 12:801411.
PMID: 35359418.


Opioid receptors are expressed not only by neural cells in the central nervous system, but also by many solid tumor cancer cells. Whether perioperative opioids given for analgesia after tumor resection surgery might inadvertently activate tumor cells, promoting recurrence or metastasis, remains controversial. We analysed large public gene repositories of solid tumors to investigate differences in opioid receptor expression between normal and tumor tissues and their association with long-term oncologic outcomes.