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Papers of the Week

2022 Mar 30

Antiinflamm Antiallergy Agents Med Chem

Evaluation Of Anti-Inflammatory Mediated Anti-Hemorrhoidal Activity of Lawsonia Inermis On Croton Oil Induced Hemorrhoidal Rats.



Hemorrhoids are a common recto-anal disorder commonly known as piles or tissue clumps in the rectum. In normal individuals, they were known as anal cushions. In the anus, they are composed of rectal blood vessels, muscles, and elastic fibres when bulged,it can cause bleeding, constipation, itching, severe pain, and bleeding in the anus. Inflammation of the anal cushion remains major pathogenesis for the development of hemorrhoids. Inflammatory mediators like neutrophils, TNF-α, and IL-6 seem to play a major role in the development of disease.