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Papers of the Week

Papers: 26 Mar 2022 - 1 Apr 2022

Animal Studies

2022 Mar 30

J Spinal Cord Med

Tropisetron attenuates neuroinflammation and chronic neuropathic pain via α7nAChR activation in the spinal cord in rats.


Zhang Y-F, Yu D, Gong X-R, Meng C, Lv J, Li Q
J Spinal Cord Med. 2022 Mar 30:1-9.
PMID: 35353023.


Tropisetron is an alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonist and is a commonly used antiemetic clinically. α7nAChRs activation modulating nociception transmissions and cholinergic anti-inflammation may decrease neuropathic pain. This study was set to investigate the effects of tropisetron on neuropathic pain and neuroinflammation as well as the underlying mechanisms in rats.