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Papers of the Week

Papers: 26 Mar 2022 - 1 Apr 2022

2022 Mar 26

Clin Epigenetics



Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain.


Goodin BR, Overstreet DS, Penn TM, Bakshi R, Quinn TL, Sims A, Ptacek T, Jackson P, Long LD, Aroke EN
Clin Epigenetics. 2022 Mar 26; 14(1):45.
PMID: 35346352.


The pathoanatomic cause of chronic low back pain (cLBP) cannot be identified for up to 90% of individuals. However, dysfunctional processing of endogenous nociceptive input, measured as conditioned pain modulation (CPM), has been associated with cLBP and may involve changes in neuronal gene expression. Epigenetic-induced changes such as DNA methylation (DNAm) have been associated with cLBP.