I am a
Home I AM A Search Login

Papers of the Week

2021 Oct-Dec

J Anaesthesiol Clin Pharmacol



Comparison of nalbuphine versus fentanyl as intrathecal adjuvant to bupivacaine for orthopedic surgeries: A randomized controlled double-blind trial.


Sharma A, Chaudhary S, Kumar M, Kapoor R
J Anaesthesiol Clin Pharmacol. 2021 Oct-Dec; 37(4):529-536.
PMID: 35340949.


Intrathecal adjuvants are used with local anesthetics to prolong the duration and provide postoperative pain relief while minimizing the dose of local anesthetic. Nalbuphine is an agonist-antagonist opioid and provides prolonged duration of analgesia with fewer side effects of fentanyl such as pruritus, nausea, and vomiting. The aim of this study was to evaluate and compare the onset and duration of sensory and motor blockade, hemodynamic effects, duration of postoperative analgesia, and adverse effects of nalbuphine and fentanyl given intrathecally with hyperbaric 0.5% bupivacaine in orthopedic lower limb surgeries.