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Papers of the Week

2022 Mar 24

Am J Med

Opioid and benzodiazepine substitutes: Impact on drug overdose mortality in Medicare population.


Gabapentinoids (GABAs) and serotonergic drugs (SSRIs/SNRIs) are increasingly being prescribed as potential substitutes to opioids and benzodiazepines (benzos), respectively, to treat co-occurring pain and anxiety disorders. The toxicities of these drug classes and their combinations are not well-understood.