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Papers of the Week

Papers: 26 Mar 2022 - 1 Apr 2022


Human Studies, Pharmacology/Drug Development

2022 Mar 28

Clin Rheumatol

Gender influence on clinical manifestations, depressive symptoms and brain-derived neurotrophic factor (BDNF) serum levels in patients affected by fibromyalgia.


Iannuccelli C, Lucchino B, Gioia C, Dolcini G, Rabasco J, Venditto T, Ioppolo F, Santilli V, Conti F, Di Franco M
Clin Rheumatol. 2022 Mar 28.
PMID: 35344113.


OBJECTIVES: Fibromyalgia (FM) is a common rheumatic disorder characterized by chronic, widespread pain associated with several not painful symptoms. The contribution of gender to the manifestation of the disease may influence the higher prevalence of FM among women. In spite of this, how patients' gender influences the clinical manifestation of FM is still not well understood. The frequent association with neuropsychiatric symptoms raised the attention on the role of neurotrophins, including the brain-derived neurotrophic factor (BDNF) as potential biomarkers of the condition. Aims of the study were to evaluate the influence of gender on clinical manifestations and to investigate BDNF serum levels as a potential biomarker of FM.