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Papers of the Week

2022 Mar

Clin Transl Allergy



Mastocytosis presenting with mast cell-mediator release-associated symptoms elicited by cyclo oxygenase inhibitors: prevalence, clinical, and laboratory features.


Rama T A, Morgado J M, Henriques A, Escribano L, Alvarez-Twose I, Sanchez-Muñoz L, Moreira A, Romão J, Órfão A, Matito A
Clin Transl Allergy. 2022 Mar; 12(3):e12132.
PMID: 35344302.


Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently avoided in mastocytosis, because of a potential increased risk for drug hypersensitivity reactions (DHRs) due to inhibition of cyclo-oxygenase (COX), subsequent depletion of prostaglandin E and release of leukotrienes.