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Papers of the Week

Papers: 26 Mar 2022 - 1 Apr 2022

Human Studies, Pharmacology/Drug Development

2022 Mar 15

Semin Arthritis Rheum


Aberrant functional connectivity between anterior cingulate cortex and left insula in association with therapeutic response to biologics in inflammatory arthritis.


Abe N, Fujieda Y, Tha KK, Narita H, Aso K, Karino K, Kanda M, Kono M, Kato M, Amengual O, Atsumi T
Semin Arthritis Rheum. 2022 Mar 15; 55:151994.
PMID: 35325802.


Brain activity is reported to be associated with individual pain susceptibility and inflammatory status, possibly contributing to disease activity assessment in inflammatory arthritis (IA) including rheumatoid arthritis (RA) and spondyloarthritis (SpA). However, what alteration of brain function associated with disease activity and therapeutic effectiveness in IA remains unclear. We aimed to identify the alterations of brain functional connectivity (FC) shared in both RA and SpA, and evaluate its relationship to anti-rheumatic treatment response using functional magnetic resonance imaging (MRI).