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Papers of the Week

2022 Mar 18

Int J Mol Sci



Anti-Inflammatory Characteristics of Local Anesthetics: Inhibition of TNF-α Secretion of Lipopolysaccharide-Stimulated Leucocytes in Human Blood Samples.


Weinschenk S, Weiss C, Benrath J, von Baehr V, Strowitzki T, Feißt M
Int J Mol Sci. 2022 Mar 18; 23(6).
PMID: 35328706.


Local anesthetics (LAs) have potent anti-inflammatory properties. Inflammatory down-regulation is crucial in diseases with overactive immune reactions, such as acute respiratory distress syndrome (ARDS) and chronic inflammation. We investigated the influence of four LAs, procaine, lidocaine, mepivacaine, and bupivacaine, on the reduction of tumor necrosis factor-alpha (TNF-α) secretion in lipopolysaccharide (LPS)-activated human leucocytes.