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Papers of the Week

Papers: 26 Mar 2022 - 1 Apr 2022

2022 Mar 25


Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis.


Fernández-de-Las-Peñas C, Navarro-Santana MJ, Curiel-Montero F, Plaza-Manzano G, Alburquerque-Sendín F, Rodrigues-de-Souza DP
Cephalalgia. 2022 Mar 25:3331024221084217.
PMID: 35332797.


This meta-analysis compared pressure pain sensitivity in trigeminal, cervical spine and remote pain-free areas between migraine patients and headache-free controls considering diagnosis (episodic versus chronic) and sex. Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds between migraine and headache-free controls. Data were extracted by two reviewers. The risk of bias and methodological quality was assessed by Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (cervical spine) and remote pain-free areas were compared. Frequency of migraine and sex were taken into account. Mean differences (MD) and random effects were calculated.