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Front Oncol


Case Report: Opportunities and Challenges of Immunotherapy in Heavily-Treated EGFR-Mutant Advanced Squamous Cell Lung Carcinoma After Progression on EGFR-TKIs and Chemotherapy.


Epidermal growth factor receptor (EGFR) mutations have a low incidence in squamous cell lung cancer (SqCLC), and the clinical efficacy of EGFR tyrosine kinase inhibitors (TKIs) in -mutated SqCLC is far less than that in -mutated lung adenocarcinoma. The treatment strategy for patients with mutated non-small cell lung cancer who are refractory to EGFR TKIs has become a current dilemma and challenge.