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Papers of the Week

2022 Mar 17

J Clin Endocrinol Metab

Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications.


Madsen A, Almås B, Bruserud IS, Oehme N H B, Nielsen C S, Roelants M, Hundhausen T, Ljubicic M L, Bjerknes R, Mellgren G, Sagen JV, Juliusson PB, Viste K
J Clin Endocrinol Metab. 2022 Mar 17.
PMID: 35299255.


Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Reference curve modeling is applicable to endocrine variables and represents a standardized method to account for variation with gender and age.