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Papers of the Week

2022 Mar 17

J Ovarian Res



BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea.


Wang S, Duan H, Li B, Hong W, Li X, Wang Y, Guo Z C
J Ovarian Res. 2022 Mar 17; 15(1):35.
PMID: 35300713.


Brain-derived neurotrophic factor (BDNF) is a known regulator of the development and maintenance of chronic pain in various chronic disorders. Together with its high-affinity tyrosine kinase type B (TrKB) receptor, BDNF is extensively expressed in the mammalian female reproductive system. However, BDNF and TrKB expression in different stages of endometriosis and the relationship between the expression of each in ectopic lesions and endometriosis pain remain unclear.