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Papers of the Week

Papers: 19 Mar 2022 - 25 Mar 2022

2022 Mar 18

Mol Imaging Biol

Evaluation of [F]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain.


Shimochi S, Keller T, Kujala E, Khabbal J, Rajander J, Löyttyniemi E, Solin O, Nuutila P, Kanaya S, Yatkin E, Grönroos TJ, Iida H
Mol Imaging Biol. 2022 Mar 18.
PMID: 35303205.


Recent studies have linked activated spinal glia to neuropathic pain. Here, using a positron emission tomography (PET) scanner with high spatial resolution and sensitivity, we evaluated the feasibility and sensitivity of N,N-diethyl-2-(2-(4-([F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a] pyrimidin-3-yl)acetamide ([F]F-DPA) imaging for detecting spinal cord microglial activation after partial sciatic nerve ligation (PSNL) in rats.