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Papers of the Week

Papers: 12 Mar 2022 - 18 Mar 2022

Pharmacology/Drug Development

2022 Mar 15

BMJ Open



Could the perioperative use of opioids influence cancer outcomes after surgery? A scoping review protocol.


Cascella M, Cuomo A, Bifulco F, Perri F, Carbone F, Aprea M, Forte C A, Fiore M
BMJ Open. 2022 Mar 15; 12(3):e054520.
PMID: 35292495.


During and after general anaesthesia, opioids are commonly used for pain treatment. Since preclinical studies underlined the potential immunosuppressive activity of these drugs, it was postulated that their perioperative administration could influence cancer outcomes after surgery. Nevertheless, clinical data have been extrapolated mainly from retrospective analyses. Consequently, the precise link between perioperative opioid use and cancer recurrence/metastasis or cancer-related mortality/morbidity is still an unsolved issue.