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Papers of the Week

Papers: 12 Mar 2022 - 18 Mar 2022

2022 Mar 11

Neurophysiol Clin

Non-invasive insular stimulation for peripheral neuropathic pain: Influence of target or symptom?


Martins da Cunha P H, Dongyang L, Fernandes A M, Thibes R B, Sato J, Tanaka H, Dale C, da Lapa J D S, de Morais A D S, Soares F H C, Aparecida da Silva V, Graven-Nielsen T, Teixeira M J, de Andrade D C
Neurophysiol Clin. 2022 Mar 11.
PMID: 35288018.


The posterior-superior insula (PSI) has been shown to be a safe and potentially effective target for neuromodulation in peripheral neuropathic pain (PNP) in humans and animal models. However, it remains unknown whether there is a measurable responder profile to PSI stimulation. Two factors were hypothesized to influence the response of repetitive transcranial magnetic stimulation (rTMS) of the PSI: differences in rTMS target (discrete subregions of the PSI) or PNP phenotype.