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Front Oncol


A Novel Murine Model of a High Dose Brachytherapy-Induced Actinic Proctitis.


Leite C H B, Lopes C D H, Leite C A V G, Terceiro D A, Lima G S, Freitas J A, Cunha F Q, Almeida P R C, Wong D V T, Lima-Júnior R C P
Front Oncol. 2022; 12:802621.
PMID: 35280725.


Radiation proctitis affects 1-20% of cancer patients undergoing radiation exposure due to pelvic malignancies, including prostate, gynecological and rectum cancers. The patients manifest rectal discomfort, pain, discharge, and bleeding. Notably, the efficacy of prophylactic measures remains controversial due to the lack of adequate animal models that mimic this condition.