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Papers of the Week

2022 Feb 08

Actas Dermosifiliogr

Plasma Steroids and Endocannabinoids Used as Biomarkers to Assess the Pruritus Severity of Patients With Prurigo Nodularis.


Chu L, Wang L-K, Wu Y, Yang H, Wang W, Lu Q, Deng H
Actas Dermosifiliogr. 2022 Feb 08.
PMID: 35282859.


Prurigo nodularis (PN) as an extremely pruritic and hyperplastic chronic dermatosis induces psychologically and physiologically stressful responses. PN-induced responses in the hypothalamic-pituitary-adrenal (HPA), hypothalamic-pituitary-gonadal (HPG) axes and endocannabinoid system (ECS) are abnormal. Extant studies on the PN's pathogenesis mostly focused on the PN's psychological responses. To date, the PN's physiological responses remain not been fully uncovered yet.