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Papers of the Week

2022 Mar 07

J Egypt Natl Canc Inst



Simple headache revealed a rare lymphoma: Waldenstrom macroglobulinemia with unique markers: a case report and review of the literature.


Awad AK, Elbadawy MA, Boury M, Rivera A, Motawea K, Shah J, Parnia S, Varney J
J Egypt Natl Canc Inst. 2022 Mar 07; 34(1):10.
PMID: 35253074.


Waldenstrom macroglobulinemia (WM) is a rare lymphoma with an incidence rate of 3 per million people per year, with approximately 1000 to 1500 new cases diagnosed each year in the USA. It is primarily seen in Caucasian males with a median age of 70 years old. Patients are most often asymptomatic, but WM can manifest itself with constitutional symptoms such as lethargy, bleeding, organomegaly, and neurological or fundoscopic abnormalities. WM is characterized by immunoglobulin M (IgM) monoclonal gammopathy, lymphocytic infiltration of bone marrow, and normocytic anemia due to bone marrow replacement.