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Papers of the Week

Papers: 26 Feb 2022 - 4 Mar 2022

Pharmacology/Drug Development

2022 Jan

Endocrinol Diabetes Nutr (Engl Ed)



miR-125a-5p in astrocytes attenuates peripheral neuropathy in type 2 diabetic mice through targeting TRAF6.


Kasimu A, Apizi X, Talifujiang D, Ma X, Fang L, Zhou X
Endocrinol Diabetes Nutr (Engl Ed). 2022 Jan; 69(1):43-51.
PMID: 35232559.


Elimination or blocking of astrocytes could ameliorate neuropathic pain in animal models. MiR-125a-5p, expressed in astrocyte derived extracellular vesicles, could mediate astrocyte function to regulate neuron communication. However, the role of miR-125a-5p in DPN (diabetic peripheral neuropathy) remains elusive.