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Papers of the Week

Papers: 26 Feb 2022 - 4 Mar 2022

Animal Studies, Pharmacology/Drug Development

2022 Feb 26

J Neuroinflammation



LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice.


Gavini CK, Elshareif N, Aubert G, Germanwala AV, Calcutt NA, Mansuy-Aubert V
J Neuroinflammation. 2022 Feb 26; 19(1):57.
PMID: 35219337.


Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macrophages by reducing foamy macrophages showed significant improvement of age-related degenerative changes in peripheral nerves of aged mice. We previously demonstrated that activation of the cholesterol sensor Liver X receptor (LXR) with the potent agonist, GW3965, alleviates pain in a diet-induced obesity model. We sought to test whether LXR activation may improve neuropathy in aged mice.