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Papers of the Week

Papers: 26 Feb 2022 - 4 Mar 2022

Animal Studies, Pharmacology/Drug Development

2022 Feb 23


Epidural Posterior Insular Stimulation Alleviates Neuropathic Pain Manifestations in Rats With Spared Nerve Injury Through Endogenous Opioid System.


Komboz F, Mehsein Z, Kobaïter-Maarrawi S, Chehade H-D, Maarrawi J
Neuromodulation. 2022 Feb 23.
PMID: 35219569.


Neuropathic pain (NP) is defined as constant disabling pain secondary to a lesion or disease of the somatosensory nervous system. This condition is particularly difficult to treat because it often remains resistant to most treatment strategies. Despite the recent diversification of neurostimulation methods, some patients still suffer from refractory pain syndromes. The central role of the posterior insular cortex (PI) in the modulation of pain signaling and perception has been repeatedly suggested. The objective of this study is to assess whether epidural insular stimulation (IS) could reverse NP behavior.