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Papers of the Week


2022 Feb 25


Childs Nerv Syst

Gorham-Stout disease of skull base leading to cranial settling and rhinorrhea: a case-based review.

Authors

Maroufi S F, Habibi Z, Dabbagh Ohadi M A, Mohammadi E, Nejat F
Childs Nerv Syst. 2022 Feb 25.
PMID: 35217940.

Abstract

Gorham-Stout disease (GSD) is a rare progressive osteolytic disorder, theoretically caused by lymphovascular endothelial proliferation. Spinal involvement carries a dismal prognosis because of neurological consequences. Lesions of the skull base are extremely rare and entail even more devastating prognosis due to cervical instability and cerebrospinal fluid (CSF) leakage. Due to scarcity of this condition, the aim of this study was to give an overview of skull base GSD and review the cases with such condition reported in the literature.