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Papers of the Week

2022 Feb

J Clin Orthop Trauma


Age related effects of selective and non-selective COX-2 inhibitors on bone healing.


Kigera JWM, Gichangi PB, Abdelmalek AKM, Ogeng'o JA
J Clin Orthop Trauma. 2022 Feb; 25:101763.
PMID: 35211371.


Fractures are increasing worldwide and with an aging population, are frequent in the elderly. The healing of fractures progresses through various phases including the inflammatory stage. Aging is associated with slower healing and the use of non steroidal anti-inflammatory drugs (NSAIDs) may interrupt bone healing processes. We designed a study to compare the effect of diclofenac and celecoxib on fracture callus histomorphometry in a rat model of different age groups.