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Papers of the Week

Papers: 19 Feb 2022 - 25 Feb 2022

Pharmacology/Drug Development

2022 Feb 21

J Headache Pain



Dual action of the cannabinoid receptor 1 ligand arachidonyl-2′-chloroethylamide on calcitonin gene-related peptide release.


Christiansen I M, Edvinsson JCA, Reducha PV, Edvinsson L, Haanes K A
J Headache Pain. 2022 Feb 21; 23(1):30.
PMID: 35189809.


Based on the current understanding of the role of neuropeptide signalling in migraine, we explored the therapeutic potential of a specific cannabinoid agonist. The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2'-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G-coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition.