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Papers of the Week

Papers: 19 Feb 2022 - 25 Feb 2022


Human Studies, Pharmacology/Drug Development

2022 Feb 21


Ketamine Psychedelic and Antinociceptive Effects are Connected.


Olofsen E, Kamp J, Henthorn TK, van Velzen M, Niesters M, Sarton E, Dahan A
Anesthesiology. 2022 Feb 21.
PMID: 35188952.


Ketamine produces potent analgesia combined with psychedelic effects. It has been suggested that these two effects are associated and possibly that analgesia is generated by ketamine-induced dissociation. The authors performed a post hoc analysis of previously published data to quantify the pharmacodynamic properties of ketamine-induced antinociception and psychedelic symptoms. The hypothesis was that ketamine pharmacodynamics (i.e., concentration-effect relationship as well as effect onset and offset times) are not different for these two endpoints.