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Papers of the Week

2022 Winter

Caspian J Intern Med



Pharmacokinetics study of chitosan-coated liposomes containing sumatriptan in the treatment of migraine.


Assadpour S, Akhtari J, Shiran M R
Caspian J Intern Med. 2022 Winter; 13(1):90-99.
PMID: 35178213.


Sumatriptan is a routine medication in the treatment of migraine and cluster headache that is generally given by oral or parental routes. However, a substantial proportion of patients suffer severe side effects. The aim of this study was to investigate the physicochemical characterization and pharmacokinetic parameters of a novel delivery system for sumatriptan succinate (SS) using nanoliposomes (NLs) coated by chitosan (CCLs) to optimize the formulations to enhance its bioavailability.