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Papers of the Week

2022 Feb 17

Adv Clin Exp Med

The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation.


Alay M, Sonmez M G, Sakin A, Atmaca M, Suleyman H, Yazici G N, Coban A, Suleyman B, Bulut S, Altuner D
Adv Clin Exp Med. 2022 Feb 17.
PMID: 35178903.


Hyperglycemia can be considered a determining factor in the development of diabetic neuropathy as well as neuropathic pain. There is a relationship between the excessive production of reactive oxygen species (ROS) and the pathogenesis of diabetic neuropathic pain. Taxifolin, on the other hand, is a flavonoid that has been documented to inhibit ROS production.