I am a
Home I AM A Search Login

Papers of the Week

Papers: 12 Feb 2022 - 18 Feb 2022

2022 Feb 14


Influencers in the Somatosensory System: Extrinsic Control of Sensory Neuron Phenotypes.


de Nooij JC
Neuroscientist. 2022 Feb 14:10738584221074350.
PMID: 35164585.


Somatosensory neurons in dorsal root ganglia (DRG) comprise several main subclasses: high threshold nociceptors/thermoceptors, high- and low-threshold mechanoreceptors, and proprioceptors. Recent years have seen an explosion in the identification of molecules that underlie the functional diversity of these sensory modalities. They also have begun to reveal the developmental mechanisms that channel the emergence of this subtype diversity, solidifying the importance of peripheral instructive signals. Somatic sensory neurons collectively serve numerous essential physiological and protective roles, and as such, an increased understanding of the processes that underlie the specialization of these sensory subtypes is not only biologically interesting but also clinically relevant.