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Papers of the Week

2022 Jan




Double Trouble: A Unique Case of Hypercalcemia Caused by Two Underlying Etiologies.


Ordaya EE, Arriola-Montenegro J, Arriola-Montenegro L, Anderson ML
Cureus. 2022 Jan; 14(1):e21084.
PMID: 35155033.


Hypercalcemia has a variety of causes, with primary hyperparathyroidism and malignancies being the most frequently reported. We present the case of a patient presenting with chronic abdominal pain, constipation, and weight loss who was found to have hypercalcemia. The patient was initially diagnosed with colonic actinomycosis, but further investigations revealed an intra-abdominal diffuse large B-cell lymphoma (DLBCL). We suspect that the leading cause of hypercalcemia was the DLBCL, likely exacerbated by actinomycosis. Actinomycosis and DLBCL can have a similar presentation, so misdiagnosis or coexistence of both conditions should be suspected when a lack of response to one specific therapy is observed.