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Papers of the Week

2022 Feb 11


Anti-GFAP Antibody-Associated Hypertrophic Pachymeningitis.


Tan C, Zhong M, Yao Z, Hong S, Jiang L, Jiang Y
Neuropediatrics. 2022 Feb 11.
PMID: 35148545.


 Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an inflammatory central nervous system (CNS) disorder that usually presents as steroid responsive encephalitis, meningitis, myelitis, or meningoencephalomyelitis. Hypertrophic pachymeningitis (HP) is an uncommon disorder that causes a localized or diffuse thickening of the dura mater. Depending on the etiology, HP can be idiopathic or secondary to a wide variety of other diseases. There are no reports of autoimmune GFAP astrocytopathy presenting as HP.