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Papers of the Week

Papers: 12 Feb 2022 - 18 Feb 2022

2022 Feb 12

Ann Neurol

Axonal excitability does not differ between painful and painless diabetic or chemotherapy-induced distal symmetrical polyneuropathy in a multi-centre observational study.


Themistocleous AC, Kristensen A G, Sola R, Gylfadottir S S, Bennedsgaard K, Itani M, Krøigård T, Ventzel L, Sindrup S H, Jensen T S, Bostock H, Serra J, Finnerup NB, Tankisi H, Bennett DLH
Ann Neurol. 2022 Feb 12.
PMID: 35150149.


Axonal excitability reflects ion channel function and it is proposed that this may be a biomarker in painful (versus painless) polyneuropathy. Our objective was to investigate the relationship between axonal excitability parameters and chronic neuropathic pain in deeply phenotyped cohorts with diabetic or chemotherapy induced distal symmetrical polyneuropathy.