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Papers of the Week

2022 Feb 10

JAMA Otolaryngol Head Neck Surg

Pathogenesis and Etiology of Ménière Disease: A Scoping Review of a Century of Evidence.


Rizk HG, Mehta NK, Qureshi U, Yuen E, Zhang K, Nkrumah Y, Lambert PR, Liu YF, McRackan TR, Nguyen SA, Meyer TA
JAMA Otolaryngol Head Neck Surg. 2022 Feb 10.
PMID: 35142800.


Ménière disease is a rare chronic benign disorder of the inner ear with a natural history of multiple clinical phenotypes of variable severity and a tendency to burnout with time. Although multiple treatment modalities have been shown to improve the disease process-some adversely affecting cochleovestibular function-it remains uncertain whether one, several separate, or a combination of pathophysiologic mechanisms affect the disease process. A scoping review of the evidence underlying proposed pathophysiologic mechanisms of Ménière disease is needed to determine which processes are most likely to be etiopathogenic factors.