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Papers of the Week

Papers: 5 Feb 2022 - 11 Feb 2022

2022 Feb 09


Erenumab dosage for migraine prevention: An evidence-based narrative review with recommendations.


Tepper SJ, Sheikh HU, Dougherty CO, Nahas SJ, Winner PK, Karanam A K, Blumenfeld AM, Abdrabboh A, Rasmussen S, Weiss JL, Ailani J
Headache. 2022 Feb 09.
PMID: 35137404.


Therapeutic monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor or its ligand have changed the landscape of treatment options for migraine. Erenumab is the first and only fully human monoclonal antibody designed to target and block the CGRP receptor. It is approved by the Food and Drug Administration for preventive treatment of migraine in adults. The recommended dose of erenumab is 70 mg monthly, with guidance that some patients may benefit from the 140 mg monthly dose. There is a need for information to guide clinical practice on the comparative efficacy and safety of these two dosing options.