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Papers of the Week

Papers: 5 Feb 2022 - 11 Feb 2022

Pharmacology/Drug Development

2022 Feb 08

Clin J Pain

Effects of Gabapentin Enacarbil on Postoperative Pain After Hip and Knee Arthroplasty: A Placebo-controlled Randomized Trial.


Ayad SS, Makarova N, Niazi AK, Khoshknabi DS, Stang T, Raza S, Kim DD
Clin J Pain. 2022 Feb 08.
PMID: 35132024.


Total joint arthroplasties are among the most common elective procedures in the United States, and they are associated with postoperative pain. Gabapentin enacarbil is a prodrug with an extended-release formulation that has been proposed for multimodal postoperative analgesia, but the drug's efficacy for major arthroplasties remains unclear.