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Papers of the Week

Papers: 5 Feb 2022 - 11 Feb 2022

Human Studies

2022 Feb 05

BMC Musculoskelet Disord



Duloxetine in OsteoArthritis (DOA) study: effects of duloxetine on pain and function in end-stage hip and knee OA – a pragmatic enriched randomized controlled trial.


Blikman T, Rienstra W, van Raaij TM, Ten Hagen AJ, Dijkstra B, Zijlstra WP, Bulstra SK, Stevens M, van den Akker-Scheek I
BMC Musculoskelet Disord. 2022 Feb 05; 23(1):115.
PMID: 35123461.


Some osteoarthritis (OA) patients experience inadequate pain relief from analgesics like acetaminophen and nonsteroidal anti-inflammatory drugs. This could be the result of experienced non-nociceptive centralized pain. Placebo-controlled randomized trials (RCT) have proven the effectiveness of duloxetine for OA and several chronic pain conditions where central sensitization (CS) is one of the key underlying pain mechanisms.