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Papers of the Week

2022 Jan 05

Pediatr Neurol


Reversible Cerebral Vasoconstriction Syndrome and Multisystem Inflammatory Syndrome in Children With COVID-19.


Sadeghizadeh A, Pourmoghaddas Z, Zandifar A, Tara S Z, Rahimi H, Saleh R, Ramezani S, Ghazavi M, Yaghini O, Hosseini N, Aslani N, Saadatnia M, Vossough A
Pediatr Neurol. 2022 Jan 05; 129:1-6.
PMID: 35124533.


Multisystem inflammatory syndrome in children (MIS-C) involves multiple organs and shows increased inflammatory markers. Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, several studies have reported the association between severe COVID-19 and MIS-C. Reversible cerebral vasoconstriction syndrome (RCVS) presents with thunderclap headaches and multifocal reversible vasoconstriction on imaging. RCVS is very rare in children. This article reports two cases of pediatric COVID-19 with severe MIS-C and clinical and imaging features indicative of RCVS.