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Papers of the Week

2021 Nov-Dec

Pain Rep



Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.


Lillywhite A, Woodhams SG, Gonçalves SV, Watson DJG, Li L, Burston JJ, Gowler PRW, Canals M, Walsh DA, Hathway GJ, Chapman V
Pain Rep. 2021 Nov-Dec; 6(4):e956.
PMID: 35128295.


Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.