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Papers of the Week

2022 Feb 03

Am J Gastroenterol

Transient Lymphocytic Colitis following SARS-CoV2 mRNA vaccine.


Chey SW, Westerhoff M, Chey WD
Am J Gastroenterol. 2022 Feb 03.
PMID: 35130188.


This is the first scientific report describing lymphocytic colitis following administration of the Pfizer SARS-CoV2 mRNA vaccine. The patient developed liquid stools, abdominal pain, and nausea within 24-hours of receiving the second dose. Symptoms were persistent for 3 months but improved 113 days post-onset. Lab profiles and GI PCR were normal. EGD and colonoscopy performed 98 days post-onset revealed patchy erythema in the descending colon and rectosigmoid. Mucosal evaluation revealed lymphocytic colitis. Review of the Vaccine Adverse Event Reporting System revealed 5 cases of microscopic colitis following the second mRNA dose. This report and VAERS cases suggest providers should consider microscopic colitis in the differential diagnosis of patients with severe, persistent diarrhea following the SARS-CoV2 mRNA vaccine.