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Papers of the Week
The E3 protein ubiquitin ligase Itch is a potential target in myeloid malignancies with marrow fibrosis.
Abstract
The underlying mechanism of myeloid malignancies like myelodysplastic syndrome (MDS) and acute myelocytic leukemia (AML) with bone marrow (BM) fibrosis (hereafter referred to as MDS-F and AML-F) is not fully understood. This study aimed to investigate the role of the E3 protein ubiquitin ligase Itch in the pathogenesis of these diseases preliminarily.