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Papers of the Week

Papers: 29 Jan 2022 - 4 Feb 2022

Pharmacology/Drug Development

2022 Feb 01

Brain Behav

Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.


Zhao S, Wang F, Wang L, Xu Y, Lv L, Duan W, Bai R, Meng Z, Shao X
Brain Behav. 2022 Feb 01:e2464.
PMID: 35106976.


Brachial plexus avulsion significantly increased brain-derived neurotrophic factor (BDNF) release in the spinal cord. Here we investigated the involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain caused by BPA injury. We hypothesized that activation of BDNF-TrkB may inhibit neuronal excitability by downregulating KCC2 to maintain a high intracellular Cl-concentration. We established a neuropathic pain rat model by avulsion of the lower trunk brachial plexus, and investigated the effects of the TrkB-specific antibody K-252a on the expression of BDNF, TrkB, and KCC2.