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Papers of the Week

2021 Oct

Iran J Basic Med Sci



Neurotropin alleviates rat osteocarcinoma pain via PX receptor activation in the midbrain periaqueductal gray.



Clinically effective analgesia treatment for patients afflicted with osteocarcinoma lessens the intensity of pain. The midbrain periaqueductal gray (PAG) plays a critical role in pain modulation, and activation of PX receptors in this region mediates pain processing. Neurotropin is a small molecule drug used for analgesic treatment of a number of chronic pain conditions. The present study aims at determining whether PX receptor activation in PAG is responsible for the analgesic effect of neurotropin in rats with osteocarcinoma pain.