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J Saudi Heart Assoc



Iatrogenic Withdrawal Syndrome in the Pediatric Cardiac Intensive Care Unit: Incidence, Risk Factors and Outcome.


Habib E, Almakadma A H, Albarazi M, Jaimon S, Almehizia R, Al Wadai A, Abouelella R
J Saudi Heart Assoc. 2021; 33(4):251-260.
PMID: 35083114.


Critically ill children and neonates routinely receive opioids and benzodiazepines for analgesia and sedation in the pediatric intensive care unit (PICU). Prolonged opioid therapy often leads to tolerance and is associated with iatrogenic withdrawal syndrome (IWS) when opioids and benzodiazepines are weaned or discontinued. Our aim is to study the incidence, risk factors and outcome of IWS following use of a withdrawal protocol on pediatric patients after cardiac surgery.