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Papers of the Week


2022 Jan 27


Anesth Analg

Wound Infusion of 0.35% Levobupivacaine Reduces Mechanical Secondary Hyperalgesia and Opioid Consumption After Cesarean Delivery. A Prospective, Randomized, Triple-Blind, Placebo-Controlled Trial.

Authors

Gómez-Ríos MÁ, Codesido-Barreiro P, Seco-Vilariño C, Calvín-Lamas M, Curt-Nuño F, Nieto-Serradilla L, Rabuñal-Álvarez MT, Fernández-Rodríguez F, Peteiro-Cartelle J, Pensado-Boo R, Bou G, Pensado-Castiñeiras A, Casans-Francés R
Anesth Analg. 2022 Jan 27.
PMID: 35086112.

Abstract

Some patients still report moderate-to-severe postoperative pain after cesarean delivery. Local anesthetic wound infusion improves acute pain and might act on peripheral and central sensitization mechanisms; however, no studies have proved this hypothesis. We evaluated the potential benefits of continuous wound infusion of levobupivacaine after cesarean delivery on secondary hyperalgesia (primary end point) and primary hyperalgesia, pain relief, persistent pain, and inflammatory and metabolic stress response.