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Papers of the Week

2022 Jan 28

J Oncol Pharm Pract

Papilledema and idiopathic intracranial hypertension due to the possible potentiation of ATRA by posaconazole in a case of acute promyelocytic leukemia.


Atas U, Aydin Ersoy M, Iltar U, Yucel O K, Turkoglu E B, Salim O
J Oncol Pharm Pract. 2022 Jan 28:10781552221076756.
PMID: 35088649.


Idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) is a rare side effect of all-trans retinoic acid (ATRA). IIH cases have been observed after the concomitant use of ATRA with azole group antimicrobials such as fluconazole and voriconazole. Here, we discuss about the diagnosis and treatment process of the IIH emerging in a young acute promyelocytic leukemia (APL) case with the ATRA impact, which can be increased by posaconazole.