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Papers of the Week
Low dose naloxone for pruritus in systemic sclerosis: Case series and literature review.
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Abstract
Pruritus is a common symptom in patients with systemic sclerosis and has a tremendous effect on the quality of life. Nevertheless, current therapeutic options are limited. The pathogenesis of pruritus in systemic sclerosis is not completely understood; however, opiate-mediated neurotransmission has been postulated to be involved.