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Papers of the Week

Papers: 22 Jan 2022 - 28 Jan 2022

2022 Jan 21

Br J Anaesth

Postoperative pain facilitates rat C-fibre activity-dependent slowing and induces thermal hypersensitivity in a sex-dependent manner.


Postoperative pain is a common clinical problem that, in preclinical studies, has almost exclusively been studied in males. Altered C-fibre activity-dependent slowing (ADS) is a potential underlying mechanism, given it is altered after tissue inflammation and nerve injury, but this has not been explored post-incision. We therefore investigated the effect of hind-paw incision on C-fibre ADS in both sexes and the involvement of voltage-gated sodium channels (Na) as they contribute to ADS. We also assessed mechanical and thermal sensitivity post-incision in both sexes.