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Papers of the Week


Papers: 22 Jan 2022 - 28 Jan 2022


Pharmacology/Drug Development


2022 Jan 25


Headache

Does “wearing off” of efficacy occur in galcanezumab-treated patients at the end of the monthly treatment cycle? Post hoc analyses of four phase III randomized trials.

Authors

Ailani J, Kuruppu DK, Rettiganti M, Oakes T, Schroeder K, Wietecha L, Port M, Blumenfeld AM
Headache. 2022 Jan 25.
PMID: 35076090.

Abstract

The purpose of this study was to propose a definition of "wearing off" at the individual patient-level and determine the percentage of patients with migraine who experience "wearing off" of efficacy of galcanezumab at the end of a treatment cycle using this predefined threshold.