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Papers of the Week

Papers: 15 Jan 2022 - 21 Jan 2022

Animal Studies, Pharmacology/Drug Development

2022 Jan 19

Psychopharmacology (Berl)

Acute pain-related depression of operant responding maintained by social interaction or food in male and female rats.


Baldwin AN, Banks ML, Marsh SA, Townsend EA, Venniro M, Shaham Y, Negus SS
Psychopharmacology (Berl). 2022 Jan 19.
PMID: 35043215.


Clinically relevant pain is often associated with functional impairment and behavioral depression, including depression of social behavior. Moreover, recovery of function is a major goal in pain treatment. We used a recently developed model of operant responding for social interaction in rats to evaluate the vulnerability of social behavior to an experimental pain manipulation and the sensitivity of pain-depressed social behavior to treatment with clinically effective analgesics.